Does Phosphatidic acid really work? Research says NO!!!
Posted on November 27 2018
We recently came across a huge marketing campaign floating around on social media regarding a phospholipid called Phosphatidic Acid. We'll call it PA for short. It is claimed that PA acts as a catalyst to muscle protein synthesis or muscle building as a direct regulator of mTOR (mammalian target of rapamycin) signaling.
Research however has not fully supported these claims.1 2 3 Most of the studies, which are not peer reviewed by the way, show that PA alone does not have an affect on muscle protein synthesis. However, when PA was combined with L-Leucine and Vitamin D3, subjects did experience muscle growth and strength. The odd part about this study is, we are unable to determine how much or how little PA had an affect on muscle growth did the combination of ingredients used in the study. Even BodyBuilding.com had similar thoughts about the efficacy of PA. So what does work for muscle protein synthesis? Hands down, studies show that supplementation with Vitamin D3 and Whey Isolate Protein works.